Physical activity attenuated the association of air pollutants with telomere length in rural Chinese adults

Exposure to air pollutants (nitrogen dioxide (NO2) and particulate matters (PMs)) or physical inactivity is linked telomere length (TL) shortening. However, there a lack of research on combined effects either NO2 PMs activity (PA) TL. This study aimed explore the joint associations (NO2 PMs) PA with relative TL in rural Chinese adults. was conducted among 2704 participants aged 18–79 years China. Concentrations (PM an aerodynamics diameter ? 1.0 ?m (PM1), ?2.5 (PM2.5) ?10 (PM10)) were estimated using random forest models incorporated satellites data, meteorological land use information. Relative each participant measured by quantitative real-time polymerase chain reaction. Linear regression applied examine independent between PA, Interaction plots used depict altered NO2, PM1, PM2.5, PM10 along increasing levels. Each 1 ?g/m3 increment associated 0.038 (95% confidence intervals (CI): ?0.044, ?0.033), 0.036 CI: ?0.041, ?0.031), 0.052 ?0.059, ?0.045), 0.022 ?0.025, ?0.019) decrease all participants; similar findings observed normal glucose tolerance impaired fasting (IFG) as well type 2 diabetes mellitus (T2DM) patients. at certain levels counteracted association (NO2, PM10) IFG T2DM Long-term exposure shortening these may be